Parkinson Disease
-10%
portes grátis
Parkinson Disease
Albin, Roger L.
Oxford University Press Inc
10/2022
304
Dura
Inglês
9780190843014
15 a 20 dias
838
Descrição não disponível.
Chapter 1: Definition, History, Nosology, and Classification
Introduction and Definition
Brief History of PD
Nosology and Classification Scheme
Classification Level 1
Classification Level 2
Ambiguities and Future Directions
Conclusion
Chapter 2: Epidemiology
Introduction
Prevalence
Incidence
Mortality
Risk Factors
Implications for Understanding Etiopathogenesis and the Future Burden of PD
Chapter 3: Pathology
Introduction
The Aging Brain
Gross Pathology, Lewy Pathology, and a-Synucleinopathy
Substantia Nigra Pars Compacta Pathology
Idiopathic Lewy Body Disease (iLBD)
The Braak et al. Staging System
Synucleinopathy Outside the Brain
Non-Synuclein Pathologies
Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model
Introduction
Basic Basal Ganglia Architecture
The "Standard" Model of Basal Ganglia Pathophysiology
Complexities of Basal Ganglia Architecture
Conclusion
Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions
Introduction
Nigrostriatal Dopamine Signaling Functions
Habit Formation and Chunking
Cholinergic Projection System Dysfunctions
Serotoninergic System Dysfunctions
Conclusions and Future Challenges
Chapter 6: Genetics of Parkinson Disease
Introduction
Dominant Forms of PD
Recessive Forms of PD
GBA
PD Genetic Risk Factors
Implications of PD Genetic Research
Chapter 7: Pathogenesis
Neuronal Vulnerability
Alpha-Synuclein
The Prion-Like Hypothesis
Mitochondrial Dysfunction
Oxidative Stress
Endolysosomal Dysfunction
Neuroinflammation
Neuroprotection Trials
Conclusions
Chapter 8: Prodromal Parkinson Disease
Introduction
REM Sleep Behavior Disorder
Observational Studies
REM Sleep Behavior Disorder Cohort Studies
Genetic Cohort Studies
Autonomic Failure
Future Directions
Chapter 9: Clinical Features I - Initial Evaluation
Presentation Features
Nature of Diagnosis and Diagnostic Criteria
History and Examination
Differential Diagnosis
Treatment Responsiveness
Diagnostic Accuracy
Chapter 10: Clinical Features II - Non-Motor Features
Introduction
Cognitive Impairments
Neuropsychiatric Disorders
Sleep Disorders
Pain
Fatigue
Autonomic Disorders
Visual Disorders
Oral Health
Conclusion
Chapter 11: Clinical Features III - Natural History
Introduction
Assessing PD Progression
PD Progression - Clinically Salient Features
Subgroups
Natural History Summary
Continuing Care
End of Life Care
Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics
Introduction
Dopaminergic Neurotransmission
L-Dopa Pharmacokinetics
L-Dopa Pharmacodynamics
Peak Dose Dyskinesias
Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions
Chapter 13: Pharmacology II - Treating Parkinson Disease
Introduction
Using L-Dopa
When the Honeymoon Is Over
L-Dopa Adjuncts
Dopamine Agonists
Cholinergic Agents
Other Symptomatic Therapies
Future Directions
Chapter 14: Surgery
Introduction
Deep Brain Stimulation: Rationale and Possible Mechanisms
Deep Brain Stimulation: Procedures
Deep Brain Stimulation: STN DBS Benefits
Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS
Deep Brain Stimulation: Adverse Events
Lesional Procedures
Cell-Based and Gene Therapies
Future Directions
Coda: Looking Ahead
Introduction and Definition
Brief History of PD
Nosology and Classification Scheme
Classification Level 1
Classification Level 2
Ambiguities and Future Directions
Conclusion
Chapter 2: Epidemiology
Introduction
Prevalence
Incidence
Mortality
Risk Factors
Implications for Understanding Etiopathogenesis and the Future Burden of PD
Chapter 3: Pathology
Introduction
The Aging Brain
Gross Pathology, Lewy Pathology, and a-Synucleinopathy
Substantia Nigra Pars Compacta Pathology
Idiopathic Lewy Body Disease (iLBD)
The Braak et al. Staging System
Synucleinopathy Outside the Brain
Non-Synuclein Pathologies
Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model
Introduction
Basic Basal Ganglia Architecture
The "Standard" Model of Basal Ganglia Pathophysiology
Complexities of Basal Ganglia Architecture
Conclusion
Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions
Introduction
Nigrostriatal Dopamine Signaling Functions
Habit Formation and Chunking
Cholinergic Projection System Dysfunctions
Serotoninergic System Dysfunctions
Conclusions and Future Challenges
Chapter 6: Genetics of Parkinson Disease
Introduction
Dominant Forms of PD
Recessive Forms of PD
GBA
PD Genetic Risk Factors
Implications of PD Genetic Research
Chapter 7: Pathogenesis
Neuronal Vulnerability
Alpha-Synuclein
The Prion-Like Hypothesis
Mitochondrial Dysfunction
Oxidative Stress
Endolysosomal Dysfunction
Neuroinflammation
Neuroprotection Trials
Conclusions
Chapter 8: Prodromal Parkinson Disease
Introduction
REM Sleep Behavior Disorder
Observational Studies
REM Sleep Behavior Disorder Cohort Studies
Genetic Cohort Studies
Autonomic Failure
Future Directions
Chapter 9: Clinical Features I - Initial Evaluation
Presentation Features
Nature of Diagnosis and Diagnostic Criteria
History and Examination
Differential Diagnosis
Treatment Responsiveness
Diagnostic Accuracy
Chapter 10: Clinical Features II - Non-Motor Features
Introduction
Cognitive Impairments
Neuropsychiatric Disorders
Sleep Disorders
Pain
Fatigue
Autonomic Disorders
Visual Disorders
Oral Health
Conclusion
Chapter 11: Clinical Features III - Natural History
Introduction
Assessing PD Progression
PD Progression - Clinically Salient Features
Subgroups
Natural History Summary
Continuing Care
End of Life Care
Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics
Introduction
Dopaminergic Neurotransmission
L-Dopa Pharmacokinetics
L-Dopa Pharmacodynamics
Peak Dose Dyskinesias
Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions
Chapter 13: Pharmacology II - Treating Parkinson Disease
Introduction
Using L-Dopa
When the Honeymoon Is Over
L-Dopa Adjuncts
Dopamine Agonists
Cholinergic Agents
Other Symptomatic Therapies
Future Directions
Chapter 14: Surgery
Introduction
Deep Brain Stimulation: Rationale and Possible Mechanisms
Deep Brain Stimulation: Procedures
Deep Brain Stimulation: STN DBS Benefits
Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS
Deep Brain Stimulation: Adverse Events
Lesional Procedures
Cell-Based and Gene Therapies
Future Directions
Coda: Looking Ahead
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
Chapter 1: Definition, History, Nosology, and Classification
Introduction and Definition
Brief History of PD
Nosology and Classification Scheme
Classification Level 1
Classification Level 2
Ambiguities and Future Directions
Conclusion
Chapter 2: Epidemiology
Introduction
Prevalence
Incidence
Mortality
Risk Factors
Implications for Understanding Etiopathogenesis and the Future Burden of PD
Chapter 3: Pathology
Introduction
The Aging Brain
Gross Pathology, Lewy Pathology, and a-Synucleinopathy
Substantia Nigra Pars Compacta Pathology
Idiopathic Lewy Body Disease (iLBD)
The Braak et al. Staging System
Synucleinopathy Outside the Brain
Non-Synuclein Pathologies
Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model
Introduction
Basic Basal Ganglia Architecture
The "Standard" Model of Basal Ganglia Pathophysiology
Complexities of Basal Ganglia Architecture
Conclusion
Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions
Introduction
Nigrostriatal Dopamine Signaling Functions
Habit Formation and Chunking
Cholinergic Projection System Dysfunctions
Serotoninergic System Dysfunctions
Conclusions and Future Challenges
Chapter 6: Genetics of Parkinson Disease
Introduction
Dominant Forms of PD
Recessive Forms of PD
GBA
PD Genetic Risk Factors
Implications of PD Genetic Research
Chapter 7: Pathogenesis
Neuronal Vulnerability
Alpha-Synuclein
The Prion-Like Hypothesis
Mitochondrial Dysfunction
Oxidative Stress
Endolysosomal Dysfunction
Neuroinflammation
Neuroprotection Trials
Conclusions
Chapter 8: Prodromal Parkinson Disease
Introduction
REM Sleep Behavior Disorder
Observational Studies
REM Sleep Behavior Disorder Cohort Studies
Genetic Cohort Studies
Autonomic Failure
Future Directions
Chapter 9: Clinical Features I - Initial Evaluation
Presentation Features
Nature of Diagnosis and Diagnostic Criteria
History and Examination
Differential Diagnosis
Treatment Responsiveness
Diagnostic Accuracy
Chapter 10: Clinical Features II - Non-Motor Features
Introduction
Cognitive Impairments
Neuropsychiatric Disorders
Sleep Disorders
Pain
Fatigue
Autonomic Disorders
Visual Disorders
Oral Health
Conclusion
Chapter 11: Clinical Features III - Natural History
Introduction
Assessing PD Progression
PD Progression - Clinically Salient Features
Subgroups
Natural History Summary
Continuing Care
End of Life Care
Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics
Introduction
Dopaminergic Neurotransmission
L-Dopa Pharmacokinetics
L-Dopa Pharmacodynamics
Peak Dose Dyskinesias
Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions
Chapter 13: Pharmacology II - Treating Parkinson Disease
Introduction
Using L-Dopa
When the Honeymoon Is Over
L-Dopa Adjuncts
Dopamine Agonists
Cholinergic Agents
Other Symptomatic Therapies
Future Directions
Chapter 14: Surgery
Introduction
Deep Brain Stimulation: Rationale and Possible Mechanisms
Deep Brain Stimulation: Procedures
Deep Brain Stimulation: STN DBS Benefits
Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS
Deep Brain Stimulation: Adverse Events
Lesional Procedures
Cell-Based and Gene Therapies
Future Directions
Coda: Looking Ahead
Introduction and Definition
Brief History of PD
Nosology and Classification Scheme
Classification Level 1
Classification Level 2
Ambiguities and Future Directions
Conclusion
Chapter 2: Epidemiology
Introduction
Prevalence
Incidence
Mortality
Risk Factors
Implications for Understanding Etiopathogenesis and the Future Burden of PD
Chapter 3: Pathology
Introduction
The Aging Brain
Gross Pathology, Lewy Pathology, and a-Synucleinopathy
Substantia Nigra Pars Compacta Pathology
Idiopathic Lewy Body Disease (iLBD)
The Braak et al. Staging System
Synucleinopathy Outside the Brain
Non-Synuclein Pathologies
Chapter 4: Pathophysiology I - Basal Ganglia Architecture and the Standard Model
Introduction
Basic Basal Ganglia Architecture
The "Standard" Model of Basal Ganglia Pathophysiology
Complexities of Basal Ganglia Architecture
Conclusion
Chapter 5: Pathophysiology II - Neurotransmitter System Dysfunctions
Introduction
Nigrostriatal Dopamine Signaling Functions
Habit Formation and Chunking
Cholinergic Projection System Dysfunctions
Serotoninergic System Dysfunctions
Conclusions and Future Challenges
Chapter 6: Genetics of Parkinson Disease
Introduction
Dominant Forms of PD
Recessive Forms of PD
GBA
PD Genetic Risk Factors
Implications of PD Genetic Research
Chapter 7: Pathogenesis
Neuronal Vulnerability
Alpha-Synuclein
The Prion-Like Hypothesis
Mitochondrial Dysfunction
Oxidative Stress
Endolysosomal Dysfunction
Neuroinflammation
Neuroprotection Trials
Conclusions
Chapter 8: Prodromal Parkinson Disease
Introduction
REM Sleep Behavior Disorder
Observational Studies
REM Sleep Behavior Disorder Cohort Studies
Genetic Cohort Studies
Autonomic Failure
Future Directions
Chapter 9: Clinical Features I - Initial Evaluation
Presentation Features
Nature of Diagnosis and Diagnostic Criteria
History and Examination
Differential Diagnosis
Treatment Responsiveness
Diagnostic Accuracy
Chapter 10: Clinical Features II - Non-Motor Features
Introduction
Cognitive Impairments
Neuropsychiatric Disorders
Sleep Disorders
Pain
Fatigue
Autonomic Disorders
Visual Disorders
Oral Health
Conclusion
Chapter 11: Clinical Features III - Natural History
Introduction
Assessing PD Progression
PD Progression - Clinically Salient Features
Subgroups
Natural History Summary
Continuing Care
End of Life Care
Chapter 12: Pharmacology I - L-Dopa Pharmacokinetics and Pharmacodynamics
Introduction
Dopaminergic Neurotransmission
L-Dopa Pharmacokinetics
L-Dopa Pharmacodynamics
Peak Dose Dyskinesias
Interactions of L-Dopa Pharmacokinetics, Pharmacodynamics, and Disease Progression Summary and Future Directions
Chapter 13: Pharmacology II - Treating Parkinson Disease
Introduction
Using L-Dopa
When the Honeymoon Is Over
L-Dopa Adjuncts
Dopamine Agonists
Cholinergic Agents
Other Symptomatic Therapies
Future Directions
Chapter 14: Surgery
Introduction
Deep Brain Stimulation: Rationale and Possible Mechanisms
Deep Brain Stimulation: Procedures
Deep Brain Stimulation: STN DBS Benefits
Deep Brain Stimulation: GPi DBS Benefits and STN vs GPi DBS
Deep Brain Stimulation: Adverse Events
Lesional Procedures
Cell-Based and Gene Therapies
Future Directions
Coda: Looking Ahead
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.
