Epigenetics, Nuclear Organization & Gene Function

Part I
An introduction to epigenetics and epigenetic regulation
1: Epigenetic phenomena in fungi, plants and animals
2: The basic structure of chromatin
3: The basic mechanism of gene transcription
Part II
Transcription is regulated by epigenetic mechanisms
4: Chromatin modifications and remodeling
5: Epigenetic chromatin changes and the transcription cycle
6: The role of non-coding RNAs
7: Maintenance of the active and inactive states
8: DNA methylation and gene expression
9: Regulation of domains and whole chromosomes
Part III
The interplay between transcription and nuclear structure
10: Architectural organization of the genome
11: The nuclear envelope
12: The nucleolus
13: Nuclear bodies
Part IV
Inheritance of chromatin structure and functional states
14: Chromosome replication and genomic stability
15: DNA repair and genomic stability
16: Inheritance of chromatin modifications through the cell cycle
17: Stem cells
18: Nuclear reprogramming and induced pluripotency
19: Transgenerational inheritance of epigenetic traits
Part V
Epigenetics, human health and development
20: Aging, cellular senescence and cancer: The role of genomic instability, cellular homeostasis and telomeres
21: Aging, cellular senescence and cancer: Epigenetic alterations and nuclear remodeling
22: Developmental systems and their dysfunction

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• DNA e Genoma
• Evolução