50 Studies Every Doctor Should Know

SECTION 1 Preventive Medicine
1. Preventing Diabetes: The Diabetes Prevention Program
2. A Comparison of Different Dieting Strategies
3. Aspirin for the Primary Prevention of Cardiovascular Disease
4. Postmenopausal Hormone Therapy: The Women's Health Initiative
5. The European Randomized Study of Screening for Prostate Cancer (ERSPC)
6. The Cochrane Review of Screening Mammography
7. Low-Dose CT Screening for Lung Cancer: The National Lung Screening Trial (NLST)

SECTION 2 Internal Medicine
8. Arrhythmia Suppression following Myocardial Infarction: The CAST Trial
9. Choosing First-Line Therapy for Hypertension: The ALLHAT Trial
10. Intensive vs. Standard Hypertension Management: The SPRINT Trial
11. Statins in Healthy Patients: The HOPE-3 Trial
12. Beta Blockers for Systolic Heart Failure: The MERIT-HF Trial
13. Initial Treatment of Stable Coronary Artery Disease: The ISCHEMIA Trial
14. Treating Elevated Blood Sugar Levels in Patients with Type 2 Diabetes: The United Kingdom Prospective Diabetes Study (UKPDS)
15. Intensive versus Conservative Blood Sugar Control for Patients with Type 2 Diabetes: The ACCORD Trial
16. The African American Heart Failure Trial (A-HeFT)
17. Early versus Delayed Antiretroviral Therapy for Patients with HIV: The INSIGHT START Trial
18. Pre-Exposure Prophylaxis to Prevent HIV Transmission: The iPeEx Trial
19. Early versus Late Initiation of Dialysis: The IDEAL Trial
20. Red Cell Transfusion in Critically Ill Patients: The TRICC Trial
21. Pulmonary Artery Catheters in Critically Ill Patients
22. Opioids for Chronic Noncancer Pain: The SPACE Trial

SECTION 3 Surgery
23. Perioperative Beta Blockers in Noncardiac Surgery: The POISE Trial
24. Cardiac Stents versus Coronary Artery Bypass Surgery for Severe Coronary Artery Disease: The SYNTAX Trial
25. Carotid Endarterectomy for Asymptomatic Carotid Stenosis: The ACST Trial
26. A Trial of Arthroscopic Knee Surgery
27. Surgery versus Rehabilitation for Chronic Low Back Pain: The MRC Spine Stabilization Trial
28. Mastectomy versus Lumpectomy for Invasive Breast Cancer: The B-06 Trial
29. Long-Term Impact of Bariatric Surgery: The Swedish Obese Subjects Study

SECTION 4 Obstetrics
30. Labor Induction vs. Expectant Management at 39 Weeks Gestation: The ARRIVE Trial
31. Antepartum Glucocorticoids in Premature Labor
32. Cell-free DNA Analysis for Prenatal Diagnosis
33. Effectiveness of Long-Acting Reversible Contraception

SECTION 5 Pediatrics
34. Treatment of Acute Otitis Media in Children
35. A Trial of Early Ear Tube Placement in Children with Persistent Otitis Media
36. Inhaled Corticosteroids for Mild Persistent Asthma: The START Trial
37. The Multimodal Treatment Study of Children with Attention Deficit/ Hyperactivity Disorder (MTA)
38. Vaccines and Autism: A Meta-Analysis
39. Preventing Peanut Allergies with Early Peanut Consumption in Infants: The Leap Trial

SECTION 6 Radiology
40. Early Imaging for Back Pain in Older Adults: The BOLD Study
41. Screening for Coronary Artery Disease in Asymptomatic Patients with Diabetes: The DIAD Study
42. Pediatric Computed Tomography, Radiation Exposure and Estimated Cancer Risk
43. Identifying Children with Low-Risk Head Injuries Who Do Not Require Computed Tomography

SECTION 7 Neurology and Psychiatry
44. Thrombolysis 3 to 4.5 Hours after an Acute Ischemic Stroke: The ECASS III Trial
45. Intra-Arterial Treatment for Acute Ischemic Stroke: The MR CLEAN Trial
46. Initial Treatment of Depression: The STAR*D Trial
47. Behavioral versus Pharmacological Treatment for Insomnia in the Elderly

SECTION 8 Systems-Based Practice
48. Reducing Catheter-Related Blood Stream Infections in the Intensive Care Unit: The Keystone ICU Project
49. Early Palliative Care in Non-Small-Cell Lung Cancer
50. Directly Observed Therapy for the Treatment of Tuberculosis in Baltimore

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• Medicina interna e clínica